human coronavirus 229E – Communicable Diseases Research

Survival of human coronavirus 229E at different temperatures on various food-contact surfaces and food and under simulated digestive conditions

Article

Published on 2022-12-012023-07-10
Journal: Food Research International (Ottawa, Ont.)
[Category] COVID19(2023년),

[키워드] COVID-19 food Food-contact surface human coronavirus 229E SARS-CoV-2 Simulated digestive fluid.
[DOI] 10.1016/j.foodres.2022.112014 PMC 바로가기

Impact of SARS-CoV-2 Spike Mutations on Its Activation by TMPRSS2 and the Alternative TMPRSS13 Protease

Article

Published on 2022-08-302022-11-16
Journal: mBio
[Category] SARS, 변종, 치료기술,

[키워드] 229E Activation acute respiratory syndrome affected airway being benefit Calu-3 cell change changes in cleavage conserved coronavirus creating Critical Delta dibasic experiment favor functional fusion peptide had no help host cell human coronavirus 229E humans immune evasion immunogenic Impact influence less MERS-CoV Middle East motif mutant Mutation mutations new SARS-CoV-2 no difference omicron pathogenic protease Proteases Protein pseudovirus pseudovirus entry reduced remained residue residues respiratory syndrome coronavirus reverse effect SARS-CoV-2 SARS-CoV-2 spike sequence shown spike spike functioning Spike protein spike protein. Surveillance the SARS-CoV-2 TMPRSS13 TMPRSS13 protease TMPRSS2 Tolerance variant variants Variation virus entry Wuhan-Hu-1
[DOI] 10.1128/mbio.01376-22 PMC 바로가기

Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19

Enoxaparin은 COVID-19에 대한 유망한 약물 조합인 TMPRSS2의 알파-1-항트립신 억제를 증가시킵니다.

Article

Published on 2022-03-252022-09-11
Journal: Scientific Reports
[Category] SARS, 변종, 진단, 치료법,

[키워드] affected alpha-1-antitrypsin anti-inflammatory activity antitrypsin Cell cells cleave complex consequence Coronavirus infection COVID-19 crystal structure drug combination ENhance enoxaparin epithelial cell epithelial cells hAEC HCoV HCoV-229E HEK293T cell HEK293T cells heparin Human coronavirus human coronavirus 229E immunostaining Infection Inflammatory less molecular nafamostat Neutralizing nucleocapsid protein overexpressing Plaque assay primary human airway Primary human airway epithelial cells quantified reactive required SARS-CoV-2 SARS-CoV-2 mutations Serine serine protease severe COVID-19 Spike protein the cell the spike protein therapy TMPRSS2 TMPRSS2 inhibitor Treatment Viral viral entry virus was determined
[DOI] 10.1038/s41598-022-09133-9 PMC 바로가기 [Article Type] Article

A UV-LED module that is highly effective at inactivating human coronaviruses and HIV-1

Short Report

Published on 2022-02-102022-10-28
Journal: Virology Journal
[Category] Coronavirus,

Efficacy of an antimicrobial surface coating against human coronavirus 229E and SARS-CoV-2

인간 코로나바이러스 229E 및 SARS-CoV-2에 대한 항균 표면 코팅의 효능

Article

Published on 2021-12-012022-09-11
Journal: American journal of infection control
[Category] SARS, 치료제,

Pannexin-1 channel opening is critical for COVID-19 pathogenesis

Article

Published on 2021-11-192022-10-30
Journal: iScience
[Category] COVID-19,

Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

비교 게놈 분석은 코로나 바이러스 감염에 대한 다양한 수준의 포유류 적응을 보여줍니다.

Comparative Study

Published on 2021-11-182022-09-10
Journal: PLoS Computational Biology
[Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 229E ACE2 ACE2 protein ACE2 proteins acting adaptation adaptive Affect Amino acid amino acid substitution amino acid substitutions aminopeptidase aminopeptidase N analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Animal host APN bats binding causative agent cause caused cellular receptor Chinese Chinese Horseshoe bats clade class common cold Comparative coronavirus coronavirus Coronavirus infection Coronaviruses COVID-19 Evidence evidence of Evolution genomic Genomic analysis HCoV HCoV-229E Health horseshoe horseshoe bats Host host receptor host susceptibility hosts Human coronavirus human coronavirus 229E Interaction Lineage lineages mammal mammalian pathogen Pathogens pattern Phylogeny primates Protein receptor Research reservoir resistance to infection resistance to infections respiratory Respiratory Coronavirus reveal rodent rodents SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SARS-like coronaviruses SARS-like virus SARS-like viruses severe acute respiratory coronavirus severe acute respiratory coronavirus 2 severity of symptom shown species Spike protein susceptible symptomatic disease the SARS-CoV-2 these viruses Tolerance Variation Viral viral entry viral infection viral infections Viral vector virus virus viruses zoonotic origin
[DOI] 10.1371/journal.pcbi.1009560 PMC 바로가기 [Article Type] Comparative Study

A phenomics approach for antiviral drug discovery

Methodology Article

Published on 2021-08-022022-10-27
Journal: BMC Biology
[Category] COVID-19,

[키워드] Analysis Anti-viral antibody Antiviral Antiviral compound antiviral drug antiviral drugs antivirals approach can be used Cell Painting compounds consequence CoV-229E COVID-19 pandemic drug drug candidates Drug discovery Drug screening Effect effective Efficacy enzymatic activity fibroblast Health Host host cell host cells human coronavirus 229E human lung identify majority methodology Morphological Morphological profiling nine non-infected non-infected cells Painting Phenomics phenotypic Proteins protocol Result reversed Spread supplementary material tested therapeutic drug Toxicity viral infection viral infections virus virus infection
[DOI] 10.1186/s12915-021-01086-1 PMC 바로가기 [Article Type] Methodology Article

A phenomics approach for antiviral drug discovery

Methodology Article

Published on 2021-08-022022-10-27
Journal: BMC Biology
[Category] Coronavirus, COVID-19, Fulltext, SARS,

[키워드] Analysis Anti-viral antibody Antiviral Antiviral compound antiviral drug antiviral drugs antivirals approach can be used Cell Painting compounds consequence CoV-229E COVID-19 pandemic drug drug candidates Drug discovery Drug screening Effect effective Efficacy enzymatic activity fibroblast Health Host host cell host cells human coronavirus 229E human lung identify majority methodology Morphological Morphological profiling nine non-infected non-infected cells Painting Phenomics phenotypic Proteins protocol Result reversed Spread supplementary material tested therapeutic drug Toxicity viral infection viral infections virus virus infection
[DOI] 10.1186/s12915-021-01086-1 PMC 바로가기 [Article Type] Methodology Article

Assessment of Antiviral Coatings for High-Touch Surfaces by Using Human Coronaviruses HCoV-229E and SARS-CoV-2

Methods

Published on 2021-07-212022-10-28
Journal: Applied and Environmental Microbiology
[Category] COVID-19, SARS,